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Diabetes

The World Health Organization recognizes three main forms of diabetes mellitus: type 1, type 2, and gestational (occurring during pregnancy), which have similar signs, symptoms, and consequences, but different causes. Ultimately, all forms are due to the beta cells of the pancreas being unable to produce sufficient insulin to prevent hyperglycemia.

Type 1 is usually due to autoimmune destruction of the pancreatic beta cells, which produce insulin. Type 2 is characterized by insulin resistance in target tissues, but some impairment of beta cell function is necessary for its development. Gestational is similar to type 2, in that it involves insulin resistance; the hormones of pregnancy can cause insulin resistance in women genetically predisposed to developing this condition.

Gestational diabetes typically resolves with delivery of the child, however types 1 and 2 diabetes are chronic conditions. All types have been treatable since insulin became medically available in 1921.

Type 1, in which insulin is not secreted by the pancreas, is directly treatable only with injected or inhaled insulin, although dietary and other lifestyle adjustments are part of management.

Type 2 may be managed with a combination of dietary treatment, tablets and injections and, frequently, insulin supplementation.

Insulin

While insulin was originally produced from natural sources such as porcine pancreas, most insulin used today is produced through genetic engineering, either as a direct copy of human insulin, or human insulin with modified molecules that provide different onset and duration of action. Insulin can also be delivered continuously by a pump surgically embedded under the skin.

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It can cause many complications. Acute complications may occur if the disease is not adequately controlled. Serious long-term complications include cardiovascular disease, chronic renal failure, retinal damage, nerve damage, and micro-vascular damage, which may cause impotence and poor healing. Poor healing of wounds, particularly of the feet, can lead to gangrene, which may require amputation.

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Adequate treatment, as well as increased emphasis on blood pressure control and lifestyle factors such as not smoking and keeping a healthy body weight, may improve the risk profile of most aforementioned complications.

In the developed world, diabetes is the most significant cause of adult blindness in the non-elderly, the leading cause of non-traumatic amputation in adults, and diabetic nephropathy is the main illness requiring renal dialysis.

Signs and symptoms

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The classical triad of symptoms are, respectively, frequent urination; increased thirst and consequent increased fluid intake; and increased appetite. Symptoms may develop quite rapidly in type 1, particularly in children. However, in type 2 the symptoms develop much more slowly and may be subtle or completely absent. Type 1 may also cause weight loss and irreducible fatigue. These symptoms can also manifest in type 2 in patients where the disease is poorly controlled.

When the glucose concentration in the blood is raised beyond the renal threshold, re-absorption of glucose is incomplete, and part of the glucose remains in the urine. This increases the osmotic pressure of the urine and inhibits the resorption of water by the kidney, resulting in increased urine production and increased fluid loss. Lost blood volume will be replaced osmotically from water held in body cells, causing dehydration and increased thirst.

Prolonged high blood glucose causes glucose absorption, which leads to changes in the shape of the lenses of the eyes, resulting in vision changes. Blurred vision is a common complaint leading to a diabetes diagnosis; type 1 should always be suspected in cases of rapid vision change whereas type 2 is generally more gradual, but should still be suspected.

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